Dilip Joshi as Jethalal Champaklal Gada: He is a Gujarati Jain businessman from Bhachau, Gujarat who runs a store, Gada Electronics. He is happily married to Daya but has a crush on Babita Iyer, his neighbor. He is the son of Champaklal Jayantilal Gada, Tapu's Father and best friend of Taarak Mehta. (2008–present)

Disha Vakani as Daya Jethalal Gada: Jethalal's wife, Tapu's mother, Champaklal's daughter in law and Sunderlal's sister. Daya is a Garba Queen. Initially shown to be extremely dumb but later becomes more mature. She is from Ahmedabad, Gujarat. (2008–2018,2019)

Bhavya Gandhi as Tipendra "Tapu" Jethalal Gada(2008–2017): son of Jethalal and Daya. He is the leader of "Tapu Sena". Raj Anadkat replaced Gandhi as Tipendra. (2017–present)

Amit Bhatt as Champaklal Jayantilal Gada: Jethalal's father and Tipendra's grandfather. He is from Bhachau (Kutch), Gujarat. He often scolds Jethalal for his laziness and carelessness. (2008–present)

Mandar Chandwadkar as Aatmaram Tukaram Bhide: A home tutor from Ratnagiri, Maharashtra and Gokuldham Society's only Secretary. Madhavi's husband and Sonu's father. He is always stressed about his work. (2008–present)

Sonalika Joshi as Madhavi Aatmaram Bhide: Aatmaram's wife is a businesswoman who sells achchar (pickles) and papad (papadum, a seasoned flatbread, with pickles.) She is the mother of Sonu. (2008–present)

Jheel Mehta as Sonalika "Sonu" Aatmaram Bhide(2008–2012): Bhide and Madhvi's daughter, member of Tapu Sena. Nidhi Bhanushali replaced Jheel Mehta. (2012–2019) Palak Sindhwani replaced Bhanushali.(2019–present)

Nirmal Soni as Dr. Hansraj Baldevraj Hathi: Hathi, which means "elephant" in Hindi, is an overweight doctor from Bihar. He loves to eat. (2008–2009; 2018–present) Kavi Kumar Azad replaced Nirmal Soni as Dr. Hathi. (2009–2018) and Soni took on the role of Hathi again due to Azad's death in 2018.

Ambika Ranjankar as Komal Hathi: Dr. Hathi's wife and Goli's mother. (2008–present)

Kush Shah as Gulabkumar "Goli" Hathi: Dr. Hathi and Komal's son who also loves eating. He is a member of Tapu Sena. (2008–present)

Gurucharan Singh Sodhi as Roshan Singh Harjeet Singh Sodhi:[10] A mechanic who owns a car garage. He hails from Amritsar, Punjab, and has a Parsi wife who is also named Roshan. He loves to do party (2008–2013; 2014–2020) Laad Singh Maan replaced Gurucharan Singh as Sodhi. (2013–2014) Balwinder Singh Suri replaced Gurucharan Singh as Sodhi. (2020–present)

Jennifer Mistry Bansiwal as Roshan Kaur Sodhi: Sodhi's wife and Gogi's mother. She is a Parsi woman. (2008–2013; 2016–present) Dilkhush Reporter replaced Bansiwal as Roshan.(2013–2016)

Samay Shah as Gurcharan Singh Sodhi (Gogi): Sodhi's son and member of Tapu Sena. (2008–present)

Tanuj Mahashabde as Krishnan Subramaniam Iyer: He is Babita's husband. Iyer is a scientist from Chennai, Tamil Nadu. He is a society committee member and Treasurer. He and Jethalal often fight but help each-other when any one of them is truly in a problem. (2008–present)

Munmun Dutta as Babita Krishnan Iyer: Iyer's wife. Jethalal has a crush on her. She is the neighbor of Jethalal, who always tries to impress her but in vain. She used to be a dancer in the film industry and is the most fashionable lady in the society. She is from Kolkata, West Bengal. (2008–present)

Shailesh Lodha as Taarak Mehta: A writer by profession, Taarak is Anjali's husband. He is Jethalal's best friend, who calls him "Fire Brigade" as he helps him through most of his problems. He is fed up with Anjali's diet food. (2008–present)

Neha Mehta as Anjali Taarak Mehta: Taarak's wife is a dietitian, who always makes diet food for him. Taarak however, is fed up with it. (2008–2020) Sunayana Fozdar replaced Neha Mehta as Anjali. (2020–present)

Shyam Pathak as Popatlal Bhagwatiprasad Pandey: He is from Bhopal, Madhya Pradesh. He works as a senior crime reporter in the Toofan Express and is the head of the digital edition of Toofan Express. He is a society committee member. He has won "The Golden Crow Award". He has been a bachelor for many years and is obsessed with getting married. He is also shown to be short-tempered. (2009–present)

Sharad Sankla as Abdul Nawab Miyaa: Owner of a grocery shop where gents of the society gather after dinner for general discussions along with drinking soda. (2008–present)

Azhar Shaikh as Pankaj "Pinku" Diwan Sahay: A member of Tapu Sena, who initially lived in Gokuldham Society but later shifted to another society. His parents Mr. Diwan Sahay and Mrs. Dipika Sahay work as secret agents for the Indian Army for many years. (2008–present)

Ghanashyam Nayak as Natwarlal Prabhashankar Undhaiwala (Nattu Kaka): Nattu is Jethalal's employee and Bagha's paternal uncle. He is from Undhai Village, Gujarat. He and Bagha always pray for Jethalal to increase their salaries. (2008–present)

Yash Patel as Magan, a worker at Gada Electronics. (2008–present)

Tanmay Vekaria as Bagheshwar "Bagha" Dadukh Undhaiwala: Jethalal's employee, Nattu's nephew, Bawri's fiancée, and love interest. (2010–present)

Monika Bhadoriya as Bawri Dhondulal Kanpuria: Bagha's fiancée and love interest. (2013–present)

Mayur Vakani as Sundarlal: Daya's brother. (2008–present)

Daya Shankar Pandey as Inspector Chalu Pandey. (2011–present)